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Ruscogenin
CAS No. : 472-11-7
MCE 国际站:Ruscogenin
产品活性:Ruscogenin 是从 Ophiopogon japonicus 提取的一种重要甾体皂苷元,通过抑制 TXNIP/NLRP3 炎症体激活和 MAPK 途径减轻脑缺血诱导的血脑屏障功能障碍,Ruscogenin 具有显著的抗炎和抗血栓活性。Ruscogenin 有口服活性。
研究领域:Immunology/Inflammation
作用靶点:NOD-like Receptor (NLR)
In Vitro: Ruscogenin (0.01-40 μM; 24 h) increases the cell viability in bEnd.3 cells subjected to OGD/R.
Ruscogenin (0.01-10 μM; 24 h) reverts the endothelial barrier leakage, inhibits the expression of IL-Iβ and Caspase-1, and modulats the TXNIP/NLRP3 pathway in bEnd.3 cells subjected to OGD/R.
Ruscogenin (0.01-10 μM; 4 h) inhibits the production of ROS, and regulated the MAPK Pathway in bEnd.3 Cells subjected to OGD/R.
In Vivo: Ruscogenin (10 mg/kg; i.g.; 1 time) improves the MCAO/R-induced brain tissue injury and inhibits the expression of IL-1β and Caspase-1 and modulats the TXNIP/NLRP3.
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