MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
Tetragastrin
CAS No. : 1947-37-1
MCE 国际站:Tetragastrin
产品活性:Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) 是胃泌素的 C-末端四肽,能刺激胃液分泌。Tetragastrin 是一种胆囊收缩素 (CCK-4) 受体激动剂。Tetragastrin 具有胃黏膜保护。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Cholecystokinin Receptor
In Vitro: The antagonist of histamine H2-receptors, Cimetidine inhibits the stimulatory effect of histamine in vitro and activates Tetragastrin stimulation of the adenylate cyclase activity. Tetragastrin and histamine activate adenylate cyclase of the rat gastric mucosa via different receptors.
In Vivo: In inbred Wistar rats treated with N-methyl-N'-nitro-N-nitrosoguanidine, Tetragastrin (s.c.; 1 mg/kg; every other day) treatment significantly reduces the incidence and the number of adenocarcinomas, and has a significantly lower labelling index of the antral mucosa.
Tetragastrin has potential for enhancing gastric mucosal protection associated with mucus secretion and/or mucus synthesis on the surface mucosa of rat gastric mucosa. A significant increase in the mucin content was noted in the mucus gel and surface mucosal layer. An increase in mucin in the mucus gel and surface mucosa would thus appear due to the administration of Tetragastrin.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Anti-Obesity Compound Library | Food-Sourced Compound Library | Peptide Library | Human Metabolite Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ceruletide | Gastrin I, human | Pentagastrin | Devazepide | Sincalide | Sograzepide | L-365260 | Proglumide | SR 146131 | Nastorazepide | A71623 | Lorglumide sodium salt | Gastrin I, rat | CCK-B Receptor Antagonist 2 | Dexloxiglumide | Lintitript | Loxiglumide | Mini Gastrin I, human TFA | CI-988 hemihydrate | AG-041R | Anthramycin | AP1153 aptamer sodium | Benzotript | CCK antagonist 1 | Gastrazole
热门产品线:重组蛋白 | 药物筛选 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。