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PF-3845
CAS No. : 1196109-52-0
MCE 国际站:PF-3845
产品活性:PF-3845 是一种有效的,选择性的,不可逆和具有口服活性的脂肪酸酰胺水解酶 (FAAH) 抑制剂,Ki 值为 0.23 µM。PF-3845 是将 FAAH 的丝氨酸亲核试剂氨基甲酸酯化的共价抑制剂。PF-3845 可以减少疼痛感,炎症和焦虑/抑郁,而对运动或认知没有实质性影响。
研究领域:Metabolic Enzyme/Protease | Neuronal Signaling | Autophagy
作用靶点:FAAH | Autophagy
In Vitro: PF-3845 (0.5 nM-10 μM; 40 min) inhibits human FAAH-1 (IC50=18 nM) in a concentration-dependent manner, and shows negligible activity against FAAH-2 (IC50>10 μM) in COS-7 cells.
PF-3845 (0.1-1000 μM; 48 h) significantly decreases the Colo-205 cell viability.
In Vivo: PF-3845 (1-30 mg/kg; p.o.) produces cannabinoid receptor-dependent reductions in inflammatory pain in rat.
PF-3845 (10 mg/kg; a single i.p.) selectively inhibits FAAH in mice for up to 24 hours.
PF-3845 (10 mg/kg; a single i.p.) causes a dramatic and sustained elevation in Anandamide (AEA) in mice.
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