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Ifosfamide

CAS No. : 3778-73-2

MCE 国际站：Ifosfamide

产品活性：Ifosfamide 是一种烷化剂 (DNA alkylator)，具有广谱的抗肿瘤作用。

研究领域：Cell Cycle/DNA Damage

作用靶点：DNA Alkylator/Crosslinker

In Vitro: Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
Ifosfamide is activated by the cytochrome P450 family. Ifosfamide (0-5 mM) suppresses the viability of CYP2B1-expressing C8III-1 cells, while it is cytotoxic to the non-CYP2B1-expressing CrFK cells only at high concentration (5 mM).
CYP BM3 mutants activates Ifosfamide, and Ifosfamide shows inhibitory activity against human U2OS cells.

In Vivo: Ifosfamide (50 mg/kg, i.p.) treatment before mating increases percentage of post-implantation loss and resorbs fetuses in pregnant rats. Ifosfamide also (50 mg/kg, i.p.) decreases the progesterone in the serum of pregnant rats. However, Ifosfamide causes no obvious difference with the control rats at 25 mg/kg. Ifosfamide (25, 50 mg/kg, i.p.) induces apoptosis and histological changes in the placentas and prenatal rats, most sensitive fetal organs are the brain, liver and kidney.

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