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XRP44X

CAS No. : 729605-21-4

MCE 国际站：XRP44X

产品活性：XRP44X 抑制 Ras 诱导的转录激活，IC₅₀ 为 10 nM。XRP44X 通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。。XRP44X 是 Elk3 抑制剂；XRP44X 还对微管有影响。

研究领域：GPCR/G Protein  |  MAPK/ERK Pathway

作用靶点：Ras

In Vitro: XRP44X is an indirect inhibitor of Net phosphorylation that acts upstream from Erk-1/2 activation. XRP44X inhibits luciferase activity with the IC₅₀ of∼10 nM.
XRP44X (10 nM) inhibits cell growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells.
XRP44X (100 nM) inhibits phosphorylation of Mek-1/2 and Raf-1.

In Vivo: XRP44X may have therapeutic potential for refractory asthma.
XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, inhibits tumor growth and metastasis in mice. XRP44X inhibits tumor growth and metastasis in nude mice. XRP44X decreases the growth of tumours and the formation of metastases in nude mice.

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