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Allopurinol sodium
CAS No. : 17795-21-0
MCE 国际站:Allopurinol sodium
产品活性:Allopurinol sodium 是一种有效的口服活性黄嘌呤氧化酶 xanthine oxidase 抑制剂,IC50值为0.2-50 μM。Allopurinol sodium 可用于研究高尿酸血症和痛风。Allopurinol sodium 降低 HIF-1α 和 HIF-2α 蛋白的表达。Allopurinol sodium 显示出抗抑郁和抗伤害活性。Allopurinol sodium 具有抗利什曼原虫作用。
研究领域:Metabolic Enzyme/Protease
作用靶点:Xanthine Oxidase
In Vitro: Allopurinol sodium (0, 10, 100, 1000 µg/ml; 17 h) decreases the expression of HIF-1α and HIF-2α protein in HFF and HUVEC cells.
Allopurinol sodium (0, 10, 100, 1000 µg/ml; 24 h) reduces angiogenesis traits of HUVEC cells.
In Vivo: Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse.
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse.
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