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Cloxacillin
CAS No. : 61-72-3
MCE 国际站:Cloxacillin
产品活性:Cloxacillin 是一种口服有效的抗菌剂和 β-lactamase 抑制剂,其 IC50 值为 0.04 µM。Cloxacillin 可通过抑制 MAPKs、NF-кB 和 NLRP3 相关蛋白的激活从而抑制金黄色葡萄球菌所引起的炎症反应。
研究领域:Anti-infection
作用靶点:Beta-lactamase | Antibiotic | Bacterial
In Vitro: Cloxacillin (0-2048 µg/mL; 20-24 h) shows good antibacterial activity for S. aureus 8325-4 and DU1090 with MIC values both of 0.125 µg/mL.
Cloxacillin (0.015625 μg/mL; 6 h) inhibits the hemolytic activity of Hlα in vitro, and this inhibition is not only more pronounced when combined with TZ and TZ, but also suppresses the inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
In Vivo: Cloxacillin (1.6125 mg/kg; s.c.; 12-h intervals for 72 h) protects mice from S. aureus peritonitis in vivo when combines with Thioridazine and Tetracycline.
Cloxacillin (7.5 mg/per; i.p.; twice daily from day 3 for 3 days) develops less severe synovitis and reduces bone erosions when combines with anti-IL-15 antibodies.
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