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Metronidazole hydrochloride
CAS No. : 69198-10-3
MCE 国际站:Metronidazole hydrochloride
产品活性:Metronidazole hydrochloride (SC 326421) 是一种具有口服活性的硝基咪唑类抗生素,能用于研究厌氧微生物的感染。Metronidazole hydrochloride 能够穿过血脑屏障,长期使用会导致炎症和骨骼肌收缩。
研究领域:Anti-infection | Apoptosis
作用靶点:Antibiotic | Bacterial | Parasite | Apoptosis
In Vitro: Metronidazole hydrochloride acts on anaerobic microorganism following: passage through the cell membrane; (b) reductive action; (c) interaction with intracellular targets; (d) release of inactive end products, exerts function with toxic nitro and nitroso derivatives.
Metronidazole hydrochloride displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli.
Metronidazole hydrochloride (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity.
Metronidazole hydrochloride (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp.
In Vivo: Metronidazole hydrochloride (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats.
Metronidazole hydrochloride (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation.
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