Opiorphin 产品活性：Opiorphin 是一种阿片类肽，是一种强效的人脑啡肽失活锌异肽酶抑制剂。Opiorphin 抑制两种脑啡肽分解外酶，人中性外肽内源性肽酶 hNEP (EC 3.4.24.11)和人外氨基肽酶 hAP-N (EC 3.4.11.2)。Opiorphin 通过激活内源性阿片依赖性传递显示出强大的镇痛活性。 产品来源： https://www.medchemexpress.cn/opiorphin.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Neprilysin In Vitro: Opiorphin (1-100 μM; the mouse isolated colon) causes contractile effects in mouse distal colon in a concentration-dependent manner and enhances the contractile response induced by Met-enkephalin. Opiorphin (0-50 μM; hNEP or hAP-N transformed HEK293 cell line) is a dual inhibitor of enkephalin-degrading hNEP and hAP-N in vitro. Opiorphin inhibits Mca-BK2 endoproteolysis by the cell-surface recombinant hNEP with an IC50 value of 33 μM. and inhibits the Ala-pNA cleavage by hAP-N with an IC50 value of 65 μM. In Vivo: Opiorphin (1.25-10 μg/kg; ICV; 0-60 min; male Kunming mice) induces potent analgesic effect in a dose- and time-dependent manner (ED50=3.22 μg/kg). 相关产品：Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Peptide Library | Metabolic Enzyme Compound Library | Protease Inhibitor Library | Membrane Protein-targeted Compound Library | Bioactive Compound Library Max | Sacubitril/Valsartan | Sacubitril | Sacubitrilat | Phosphoramidon Disodium | Racecadotril | Thiorphan | Sampatrilat | TD-0212 | (Rac)-UK-414495 | Sacubitril-13C4 hemicalcium salt | SCH 42495 racemate | SCH-42354 | Candoxatril | NEP-In-1 | NEP-IN-2 | SQ28603 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。