Oxychlororaphine 产品活性：Oxychloroaphine 可以从天然存在于土壤中的聚块泛亚菌中分离得到。Oxychloroaphine 具有广谱抗真菌活性。Oxychloroaphine 具有浓度依赖性的细胞毒性，导致细胞凋亡 (apoptosis)。Oxychloroaphine 可用于癌症的研究。 产品来源： https://www.medchemexpress.cn/oxychlororaphine.html 研究领域：Anti-infection | Apoptosis | Cell Cycle/DNA Damage | Epigenetics 作用靶点：Fungal | Apoptosis | Caspase | Bcl-2 Family | MDM-2/p53 | PARP 结构分类：其他类 | 结构分类 In Vitro: Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC50 values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM. Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein. Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase. Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antifungal Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Glutamine Metabolism Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Microbial Metabolite Library | Mitochondria-Targeted Compound Library | Transcription Factor-Targeted Library | Anti-Cancer Natural Product Library | Membrane Protein-targeted Compound Library | Cell Death Library | Anti-Hematopathy Compound Library | Multi-Target Compound Library | Mitophagy Compound Library | Bioactive Compound Library Max | MG-132 | Rapamycin | Ferrostatin-1 | Cycloheximide | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Olaparib | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | Venetoclax | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。