Geranylgeraniol 产品活性：Geranylgeraniol 是一种口服有效的维生素 K2 亚型，是甲戊酸途径 (mevalonate pathway) 的中间体。Geranylgeraniol 靶向 NF-kB 信号通路，可在动物模型中减轻脂多糖 (LPS) 诱导的小胶质细胞炎症。 产品来源： https://www.medchemexpress.cn/geranylgeraniol.html 研究领域：NF-κB 作用靶点：NF-κB 结构分类：其他类 In Vitro: Geranylgeraniol (0-10 μM; 24 h) dose-dependently suppresses the LPS-induced increase in the mRNA levels of Il-1β, Tnf-α, Il-6, and Cox-2. Geranylgeraniol (10 μM; 24 h) inhibits the phosphorylation of TAK1, IKKα/β, and NF-κB p65 proteins as well as NF-κB nuclear translocation induced by LPS while maintaining IκBα expression. Geranylgeraniol, (50 μM; 24 h) eliminates cell damage caused by Simvastatin (HY-17502) (10 µM) and Mevalonat (10 mM), and reduces the inflammatory marker and the damage of the mitochondria, maintaining its shape and component. In Vivo: Geranylgeraniol (725 mg/kg/d; p.o.; 90 d) is not toxicologically significant with a dose below 725 mg/kg/d in rats. Geranylgeraniol (483 mg/kg/d; p.o.; 10 d) suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Microbial Metabolite Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Food-Sourced Compound Library | Anti-Liver Cancer Compound Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Radioprotector Library | Bioactive Compound Library Max | Phorbol 12-myristate 13-acetate | Bortezomib | BAY 11-7082 | TAK-243 | JSH-23 | Shikonin | Sulfasalazine | Triptolide | Aspirin | Pyrrolidinedithiocarbamate ammonium | Baicalin | Dihydroartemisinin | 5-Aminosalicylic Acid | Parthenolide | CBL0137 hydrochloride | Isoginkgetin | BAY 11-7085 | Rocaglamide | Betulinic acid | SC75741 | Astaxanthin | Ergothioneine | QNZ | Andrographolide | SN50 | Nafamostat mesylate | 20(S)-Ginsenoside Rg3 | Hyperoside | Ginsenoside Rg1 | Lidocaine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。