耗材描述
Olivetol
产品活性:Olivetol 是一种天然多酚类化合物,存在于地衣中,或由一些昆虫产生。Olivetol 竞争性地抑制大麻素受体 CB1 和 CB2,抑制 CYP2C19 和 CYP2D6 的活性,IC50 值和 Ki 值分别为 15.3 μM, 7.21 μM 和 2.71 μM, 2.87 μM。
产品来源: https://www.medchemexpress.cn/Olivetol.html
研究领域:Metabolic Enzyme/Protease | Neuronal Signaling | GPCR/G Protein
作用靶点:Cytochrome P450 | Cannabinoid Receptor
来源:植物 | 其他科
结构分类:酚类 | 多酚类 | 结构分类
In Vitro: Olivetol inhibits the (S)-mephenytoin 4'-hydroxylase activity of CYP2C19 activity with an IC50 of 15.3 μM and a Ki of 2.71 μM. Olivetol also inhibits AMMC O-demethylase activity of recombinant CYP2D6 with an IC50 of 7.21 μM and a Ki of 2.87 μM.?
Olivetol is a competitive inhibitor of the cannabinoid receptors CB1 and CB2.
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