4-O-Methyl honokiol 产品活性：4-O-Methyl honokiol 是从厚朴中分离到的木脂素类化合物，为 PPARγ 的激动剂，可抑制 NF-κB 的活性，用于癌症，炎症等研究。 产品来源： https://www.medchemexpress.cn/4-O-Methyl_honokiol.html 研究领域：Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease | NF-κB 作用靶点：PPAR | NF-κB 来源：植物 | 木兰科 | 厚朴 | 植物 | 其他科 结构分类：苯丙素类 | 木脂素 | 酚类 | 单酚类 In Vitro: 4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells. In Vivo: 4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues. 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ1-42 accumulation, and activates astrocytes and microglia in LPS-injected mice brain. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Phenols Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Nuclear Receptor Compound Library | Osteogenesis Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Phorbol 12-myristate 13-acetate | Bortezomib | Retinoic acid | BAY 11-7082 | Rosiglitazone | GW9662 | TAK-243 | JSH-23 | Shikonin | Sulfasalazine | Triptolide | Aspirin | Pioglitazone | Pyrrolidinedithiocarbamate ammonium | Baicalin | GW6471 | Fenofibrate | Dihydroartemisinin | Fisetin | Pirinixic acid | T0070907 | 5-Aminosalicylic Acid | Parthenolide | CBL0137 hydrochloride | Isoginkgetin | BAY 11-7085 | Troglitazone | Rocaglamide | Betulinic acid | Daidzein 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。