耗材描述
Efmitermant alfa
产品活性:Efmitermant alfa (ACE-083) 是一种局部作用的、基于卵泡抑素的融合蛋白。Efmitermant alfa 也是一种肌肉促进剂。Efmitermant alfa 可用于肌肉疾病的研究。
产品来源: https://www.medchemexpress.cn/efmitermant-alfa.html
研究领域:Others
作用靶点:Others
In Vitro: ACE-083 (0-60 nM) has high affinity for heparin and extracellular matrix.
ACE-083 (0- 20 µg/mL) binds and potently neutralizes myostatin, activin A, activin B and growth differentiation factor 11 (GDF11) .
In Vivo: ACE-083 (i.m.; 0-100 µg; twice weekly for 4 weeks) causes localized, dose-dependent hypertrophy of the injected muscle in wild-type mice and mouse models of Charcot-Marie-Tooth disease (CMT) and Duchenne muscular dystrophy.
ACE-083 (i.m.; 0-100 µg; twice weekly for 4 weeks) also increases the force of isometric contraction in situ by the injected tibialis anterior muscle in wild-type mice and disease models and increased ankle dorsiflexion torque in CMT mice.
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