Simlukafusp alfa 产品活性：Simlukafusp alfa (FAP-IL2v) 是一种免疫细胞因子，包括一种抗成纤维细胞活化蛋白 α (FAPα) 的抗体和一种只结合 IL-2Rβγ 的 IL-2 变体。Simlukafusp alfa 是一种人 IgG1 抗体。 产品来源： https://www.medchemexpress.cn/simlukafusp-alfa.html 研究领域：Immunology/Inflammation 作用靶点：Interleukin Related In Vitro: Simlukafusp alfa (FAP-IL2v) shows binding affinity constants of 43±9 pM, 80±20 pM, 660±80 pM, 0.3 nM, 0.23 nM and 0.5 nM with huIL-2Rβγ, cyIL-2Rβγ, muIL-2Rβγ, huFAP, cyFAP and muFAP, respectively. Simlukafusp alfa (0-100 nM; 5 days) activates CD4+/CD8+ T cells and NK cells in vitro, but not preferentially Tregs. Simlukafusp alfa (0-100 nM) enhances Cetuximab (HY-P9905)-mediated antibody-dependent cellular cytotoxicity (ADCC) and Cibisatamab (HY-P99011)-mediated T-cell-dependent cellular cytotoxicity (TDCC) in vitro. In Vivo: Simlukafusp alfa (FAP-IL2v) (1 mg/kg; i.v.; weekly for 4 weeks) is efficacious in combination with therapeutic antibodies in murine models of human cancer. 相关产品：Resatorvid | Disulfiram | Polyinosinic-polycytidylic acid | Raleukin | Deucravacitinib | Dupilumab | Tocilizumab | Apilimod | Oxidopamine hydrobromide | LMT-28 | Theophylline | Secukinumab | Clofazimine | Sodium metatungstate | Benzbromarone | SC144 | Hydrocortisone hemisuccinate | LY3509754 | ODN 2216 | Muscone | Diacerein | JTE-607 | Ixekizumab | APY0201 | Risankizumab | Lysophosphatidylcholines | Ustekinumab | Fibrinogen (Bovine) 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。