Pasotuxizumab 产品活性：Pasotuxizumab (BAY 2010112) 是一种 PSMA 和 CD3 双特异性的 T 细胞接合剂 (BiTE)。Pasotuxizumab 可结合 CD3 和 PSMA，对人 CD3 和 PSMA 的 KD 分别为 9.4 nM 和 47.0 nM。Pasotuxizumab 可用于转移性去势抵抗性前列腺癌 (mCRPC) 的研究。 产品来源： https://www.medchemexpress.cn/pasotuxizumab.html 研究领域：Immunology/Inflammation 作用靶点：CD3 In Vitro: Pasotuxizumab (0-100 ng/mL approximately, 48 h) leads to activation of CD4+ and CD8+ T cell populations, with EC50s of 3.4-6.7 ng/mL for human cocultures, and 13.7-21.2 ng/mL for cynomolgus monkey cell cocultures. Pasotuxizumab (0-100 ng/mL approximately, 48 h) increases release of interferon-γ, TNF-α, IL-2 and IL-10 in T cells. In Vivo: Pasotuxizumab (0-100 ng/mL approximately, 48 h) leads to activation of CD4+ and CD8+ T cell populations, with EC50s of 3.4-6.7 ng/mL for human cocultures, and 13.7-21.2 ng/mL for cynomolgus monkey cell cocultures. Pasotuxizumab (0-100 ng/mL approximately, 48 h) increases release of interferon-γ, TNF-α, IL-2 and IL-10 in T cells. 相关产品：Teclistamab | Mosunetuzumab | Talquetamab | Epcoritamab | Solitomab | Muromonab | Teplizumab | Cibisatamab | Catumaxomab | Obrindatamab | Otelixizumab | Cevostamab | Gresonitamab | Pavurutamab | Nivatrotamab | Pacanalotamab | Voxalatamab | Anti-Mouse CD3 Antibody (17A2) | Foralumab | Linvoseltamab | Tepoditamab | Flotetuzumab | Plamotamab | Vepsitamab | Vibecotamab | Dafsolimab | Maydispenoid A | Maydispenoid B | Tidutamab | Ubamatamab 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。