Pacanalotamab 产品活性：Pacanalotamab (AMG 420；BI-836909) 是一种双特异性 T 细胞接合剂 (BiTE)，靶向 BCMA 和 CD3ɛ。BCMA 是指 B 细胞成熟抗原，而 Pacanalotamab 会将 T 细胞重定向到细胞表面的 BCMA 表达细胞。Pacanalotamab 可对人多发性骨髓瘤 (MM) 细胞系进行 T 细胞重定向裂解。 产品来源： https://www.medchemexpress.cn/pacanalotamab.html 研究领域：Immunology/Inflammation 作用靶点：CD3 In Vitro: Pacanalotamab (1 pg/mL-100 ng/mL; 24 h) induces BCMA-dependent tumor cell lysis via T cells activation. And Pacanalotamab induces dose-dependent redirected lysis of human multiple myeloma cell lines with EC90 values ranging from 16-810 pg/mL. Pacanalotamab (100 ng/mL; 24 h) induces translocation of phosphatidylserine from the inner to the outer leaflet of the plasma membrane, leading to apoptosis in MM.1R cells. In Vivo: Pacanalotamab (50 µg/kg/day; i.v. or s.c.; for 18 days) exhibits anti-tumor activity in mouse NCI-H929 xenograft model. Pacanalotamab (5 µg/kg/day; i.v. or s.c.) significant prolongs survival of mouse in mouse orthotopic L-363 xenograft model. Pacanalotamab (135 µg/kg/day for i.v. or 405 µg/kg/day for s.c.; up to 28 days) is well tolerated, and it decreases plasma cells in the bone marrow in macaque in toxicity studies. 相关产品：Teclistamab | Mosunetuzumab | Talquetamab | Epcoritamab | Solitomab | Muromonab | Teplizumab | Cibisatamab | Catumaxomab | Obrindatamab | Otelixizumab | Cevostamab | Gresonitamab | Pavurutamab | Nivatrotamab | Pasotuxizumab | Voxalatamab | Anti-Mouse CD3 Antibody (17A2) | Foralumab | Linvoseltamab | Tepoditamab | Flotetuzumab | Plamotamab | Vepsitamab | Vibecotamab | Dafsolimab | Maydispenoid A | Maydispenoid B | Tidutamab | Ubamatamab 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。