Placulumab 产品活性：Placulumab (ART621) 是一种抗 TNF α 单克隆抗体。Placulumab 具有抗炎活性，在关节炎等炎性疾病中有潜在应用。 产品来源： https://www.medchemexpress.cn/placulumab.html 研究领域：Apoptosis 作用靶点：TNF Receptor In Vitro: Placulumab (0.01-1000 µg/mL) has cytotoxicity to NS0 cells and peripheral blood mononuclear cells (PBMCs). In Vivo: Placulumab (0.3, 1, 3 and 10 mg/kg; i.p.; twice weekly for 8 weeks) has effective anti-arthritis properties in Tg197 transgenic mouse model. Pharmacokinetic (PK) parameters of Placulumab in cynomolgus macaques Route Dose (mg/kg) Exposure AUC0-336 h (ng.h/mL) Maximum concentration Cmax (ng/mL) Time of maximum concentration tmax (h) Elimination half-life t1/2 (h) Clearance CL (mL/hr/kg) Intravenous injection (Males) 50 46000000 1320000 0.167 104 0.985 Intravenous injection (Females) 50 43300000 1020000 0.211 97.4 1.06 Route Dose (mg/kg) Exposure AUC0-336 h (ng.h/mL) Dose normalize exposure AUC0-336 h (norm) Maximum concentration Cmax (ng/mL) Time of maximum concentration tmax (h) Elimination half-life t1/2 (h) Subcutaneous injection (Males) 0.5 676000 1350000 3190 50.0 120 Subcutaneous injection (Females) 0.5 445000 890000 2880 48.0 108 Subcutaneous injection (Males) 5 3940000 788000 22700 40.0 117 Subcutaneous injection (Females) 5 3840000 767000 23800 12.0 109 Subcutaneous injection (Males) 50 41600000 832000 272000 40.0 122 Subcutaneous injection (Females) 50 32300000 646000 212000 32.0 107 相关产品：Resatorvid | Shikonin | Infliximab | Fisetin | Adalimumab | Etanercept | N-Formyl-Met-Leu-Phe | Apremilast | R-7050 | Theophylline | QNZ | Nafamostat mesylate | C25-140 | Diprovocim | UCB-9260 | Brentuximab vedotin | Muscone | Certolizumab pegol | Forsythoside B | TRAF-STOP inhibitor 6877002 | Astilbin | Sinensetin | Belimumab | Geraniin | HS-276 | Adalimumab (anti-TNF-α) | Semapimod tetrahydrochloride | Mulberroside A | TNF-α (31-45), human | TNF-α-IN-2 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。