Mitazalimab 产品活性：Mitazalimab (ADC-1013; JNJ-64457107) 是 FcγR 依赖性 CD40 激动剂，具有肿瘤导向活性。Mitazalimab 激活抗原呈递细胞，例如 树突状细胞 (DC)，以启动肿瘤反应性 T 细胞。因此，Mitazalimab 诱导肿瘤特异性 T 细胞浸润并杀死肿瘤。Mitazalimab 可重塑肿瘤浸润性骨髓微环境。 产品来源： https://www.medchemexpress.cn/mitazalimab.html 研究领域：Apoptosis 作用靶点：TNF Receptor In Vitro: Mitazalimab (1 ng/mL-10 μg/mL) activates tumor associated macrophages (TAMs) in prostate tumor or ovarian tumor samples from human. In Vivo: Mitazalimab (100 μg/mouse; i.p.; single dose) activates splenic DC and B cells in Naïve hCD40tg mice, and also results expansion of OVA-specifc CD8+ T cells in OVA-rechallenged (200 μg; i.v.; 3 times for 7 days between) mice. Mitazalimab (100 and 300 μg/mouse, i.p.; on day 7, 10 and 13 post-inoculation) induces the release of proinfammatory cytokines and chemokines in the blood in MB49 (mouse bladder tumor cell line) bearing mice, and alters the composition of tumor myeloid cells, such that reduces monocytes and macrophages in favor of granulocytic cell. 相关产品：Resatorvid | Shikonin | Infliximab | Fisetin | Adalimumab | Etanercept | N-Formyl-Met-Leu-Phe | Apremilast | R-7050 | Theophylline | QNZ | Nafamostat mesylate | C25-140 | Diprovocim | UCB-9260 | Brentuximab vedotin | Muscone | Certolizumab pegol | Forsythoside B | TRAF-STOP inhibitor 6877002 | Astilbin | Sinensetin | Belimumab | Geraniin | HS-276 | Adalimumab (anti-TNF-α) | Semapimod tetrahydrochloride | Mulberroside A | TNF-α (31-45), human | TNF-α-IN-2 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。