耗材描述
Mipasetamab uzoptirine
产品活性:Mipasetamab uzoptirine (ADCT-601) 是一种 AXL 靶向的抗体-活性分子偶联物 (ADCs)。Mipasetamab uzoptirine 由人源化抗 AXL 抗体、可裂解连接子和有效的吡咯并苯二氮卓 (PBD) 二聚体细胞毒素 SG3199 组成。Mipasetamab uzoptirine 可用于癌症研究。
产品来源: https://www.medchemexpress.cn/mipasetamab-uzoptirine.html
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:TAM Receptor
In Vitro: Mipasetamab uzoptirine binds to both soluble and membranous AXL, and is rapidly internalized by AXL-expressing tumor cells, allowing release of PBD dimer, DNA interstrand cross-linking, and subsequent cell killing.
Mipasetamab uzoptirine selectively inhibits growth of AXL-positive human cancer cell lines (Panc-1, A-172, SK-LU-1, MDA-MB-231, SK-OV-3, NCI-H1299, and SN12C).
Mipasetamab uzoptirine (0 h, at 4°C) shows strong cell surface binding in SN12C cells, and colocalize well with lysosome at 1 h.
Mipasetamab uzoptirine increases DNA interstrand cross-links levels in SN12C cells.
In Vivo: Mipasetamab uzoptirine (0.3-1 mg/kg, i.v.) inhibits tumor growth in MDA-MB-231 TNBC xenograft and SN12C xenograft mice model.
Mipasetamab uzoptirine (6 mg/kg, i.v.) is well tolerated and shows excellent stability in rats.
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