Iscalimab 产品活性：Iscalimab (CFZ-533) 是一种非耗竭性 IGg1 单克隆抗体，靶向 CD40 (KD: 0.3 nM)。Iscalimab 可用于 Graves 甲状腺功能亢进症和自身免疫性疾病的研究。 产品来源： https://www.medchemexpress.cn/iscalimab.html 研究领域：Apoptosis 作用靶点：TNF Receptor In Vitro: Iscalimab (0.01-1 μg/mL, overnight) blocks rCD154-induced TNF production by primary monocyte-derived dendritic cells (moDCs), with an IC50 of 0.04 μg/mL. Iscalimab (3 days) inhibits rCD154-induced proliferation of PBMCs from humans, rhesus and cynomolgus animals with IC50s of 0.02, 0.03, and 0.01 μg/mL, respectively. Iscalimab bind CD40 on B cells from humans, rhesus and cynomolgus animals with EC50 values of approximately 0.2 μg/mL. Iscalimab (2 μg/mL, 3 h) is internalized by B cells in a CD40-dependent manner. In Vivo: Iscalimab (150 mg/kg/week, s.c, for 13 weeks) is well tolerated and does not cause any dose-limiting toxicity in rhesus monkeys. Iscalimab (10 mg/kg, i.v.) completely inhibits T cell-dependent antibody response in Rhesus monkeys. Iscalimab (30 mg/kg, i.v.) prolongs allograft survival in kidney transplant cynomolgus. 相关产品：Resatorvid | Shikonin | Infliximab | Fisetin | Adalimumab | Etanercept | N-Formyl-Met-Leu-Phe | Apremilast | R-7050 | Theophylline | QNZ | Nafamostat mesylate | C25-140 | Diprovocim | UCB-9260 | Brentuximab vedotin | Muscone | Certolizumab pegol | Forsythoside B | TRAF-STOP inhibitor 6877002 | Astilbin | Sinensetin | Belimumab | Geraniin | HS-276 | Adalimumab (anti-TNF-α) | Semapimod tetrahydrochloride | Mulberroside A | TNF-α (31-45), human | TNF-α-IN-2 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。