Ezabenlimab 产品活性：Ezabenlimab (BI-754091) 是一种抗 PD-1 单克隆抗体，结合 PD-1 的 Kd 为 6 nM (CHO 细胞)。Ezabenlimab 能够阻断 PD-1 与 PD-L1 和 PD-L2 的相互作用。Ezabenlimab 还增加 T 细胞内的 γ 干扰素分泌，抑制体内肿瘤生长。 产品来源： https://www.medchemexpress.cn/ezabenlimab.html 研究领域：Immunology/Inflammation 作用靶点：PD-1/PD-L1 In Vitro: Ezabenlimab inhibits the interaction of PD-1 to PD-L1 and PD-L2 in CHO cells with IC90s of 4.14 nM and 3.98 nM, respectively; and inhibits the interaction of PD-1 to PD-L1 and PD-L2 in cynomolgus with IC90s of 5.61 nM and 7.54 nM, respectively. Ezabenlimab increases IFN-γ secretion in primary human antigen-experienced CD3-positive T cells, with an EC50 value of 0.9 nM. Ezabenlimab (200 nM) has synergistic effect with BI 754111, resulting in further increase of IFN-γ secretion. In Vivo: Ezabenlimab (0.3-30 mg/kg; i.p.; single dose or twice per week or every 3 weeks) inhibits tumor progress and shows comparable anti-tumor activity in hPD-1 knock-in mouse model. 相关产品：Atezolizumab | Pembrolizumab | Cilengitide | Nivolumab | BMS-1 | BMS-202 | Anti-Mouse PD-1 Antibody (RMP1-14) | JQ-1 (carboxylic acid) | Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) | Durvalumab | Tomivosertib | Avelumab | Pembrolizumab (anti-PD-1) | Sulindac | CA-170 | Camrelizumab | Tislelizumab | BMS-1166 | INCB086550 | BMS-8 | Peresolimab | Fraxinellone | PD-1/PD-L1-IN-9 | Sintilimab | Toripalimab | Rosnilimab | WL12 | Evixapodlin | PROTAC PD-1/PD-L1 degrader-1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。