耗材描述
Tenatumomab
产品活性:Tenatumomab (ST2146) 是一种鼠源抗细胞粘合素 C (tenascin-C) 单克隆抗体。Tenascin-C,一种大的细胞外糖蛋白,在癌症中过度表达。Tenatumomab 已用于预靶向抗体引导放射免疫研究 (PAGRIT),并通过 PAGRIT 和直接 131 碘标记方法向肿瘤输送放射性核素。
产品来源: https://www.medchemexpress.cn/tenatumomab.html
研究领域:Others
作用靶点:Others
In Vitro: Tenascin-C is a hexameric glycoprotein found in the extracellular matrix of embryos and adults. It has preferential expression in malignant solid tumors and hematologic tumors. Tenascin-C is spatially and temporally associated with tumor neovasculars and may exert anti-adhesion and immunosuppressive activities.
Tenatumomab (2-5 μg/mL; 16 h) retains immunoreactivity upon biotinylation. And Tenatumomab can be conjugated to up to 20 biotins per mAb,maintaining >50% immunoreactivity.
In Vivo: Tenatumomab (4 μg/mouse; i.v.; single dose) shows a biodistribution associated with low and high tenascin expression in nude mice transplanted with human HT-29 colon carcinoma and/or human U-118MG glioblastoma cells, respectively.
相关产品:Digitonin | 5-Ph-IAA | FLAG peptide | 3X FLAG peptide | TCEP hydrochloride | Monocrotaline | Tocofersolan | Pronase E (Activity ≥ 7000 U/g) | DPPH | DNase I, Bovine pancreas | NMDI14 | O-Propargyl-Puromycin | Human IgG1 kappa, Isotype Control | Phytohemagglutinin | Hyaluronidase | Biotinyl tyramide | MYLS22 | Pertussis Toxin | N,N-Dimethylformamide | Kifunensine | OVA Peptide (323-339) | L-Tryptophan | 6-Aminonicotinamide | Lauryl maltose neopentyl glycol | Alkyne-phenol | Potassium oxonate | OVA Peptide(257-264) TFA | CHAPS | Teriparatide
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