Valanafusp alfa 产品活性：Valanafusp alfa (AGT-181) 是一种抗人胰岛素受体 (HIR) 和人硬糖苷酶 (IDUA) 的嵌合单克隆抗体的脑穿透重组融合蛋白。Valanafusp alfa 可用于粘多糖病 I 型 (MPS I) 的研究。 产品来源： https://www.medchemexpress.cn/valanafusp-alfa.html 研究领域：Protein Tyrosine Kinase/RTK 作用靶点：Insulin Receptor In Vitro: Valanafusp alfa (HIRMAb-IDUA) binds to the HIR extracellular domain (ECD) with an EC50 of 0.93±0.07 nM. Valanafusp alfa (HIRMAb-IDUA) (0.3 μg/mL; 48 h) reduces glycosoaminoglycan accumulation in Hurler fibroblasts by 70% as compared to healthy fibroblasts. In Vivo: Chronic dosing of Valanafusp alfa (AGT-181) (0.2-20 mg/kg; IV) has an excellent safety profile at all doses with no clinical, histologic, or laboratory findings, and no effect on glycemic control in plasma or cerebrospinal fluid. Valanafusp alfa (AGT-181) (0.2-20 mg/kg; IV) is stable, and shows rapid clearance and the high systemic volume of distribution in Rhesus monkeys. 相关产品：Insulin (human) | Insulin(cattle) | Ceritinib | Linsitinib | BMS-754807 | S961 acetate | BMS-536924 | GSK1838705A | NVP-AEW541 | GIP, human | GIP (3-42), human | GSK1904529A | Rhoifolin | NVP-ADW742 | MSDC 0160 | AVJ16 | BCTC | Insulin glargine | NVP-TAE 226 | AG1024 | GIP (1-30) amide,human acetate | NT219 | Insulin degludec | Kaempferitrin | Insulin glulisine | GIP (1-30) amide, porcine TFA | human GIP(3-30), amide TFA | Insulin aspart 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。