耗材描述
IMAB027
产品活性:IMAB027 (ASP1650) 是一种特异性抗 CLDN6 单克隆抗体,而 CLDN6 (Claudin 6) 是一种紧密连接膜蛋白,在各种人类癌症类型中异常表达,尤其是在卵巢癌中。IMAB 027 具有抗肿瘤活性,并诱导 CLDN6+ 卵巢癌和睾丸癌细胞凋亡。
产品来源: https://www.medchemexpress.cn/imab027.html
研究领域:Others
作用靶点:Others
In Vitro: IMAB027 specifically binds to CLDN6 rather than other closely related family members, such as Claudins 3, 4, and 9.
IMAB027 induces target-selective antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) in CLDN6+ ovarian and testicular cancer cell lines.
In Vivo: IMAB027 reduces tumor growth and increases overall survival in xenografted mouse tumors with human CLDN6+ cells.
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