Robatumumab 产品活性：Robatumumab (Sch 717454) 是一种 anti-human IGF-1R (胰岛素样生长因子 1 受体) 抗体。Robatumumab 具有抗肿瘤活性和抗癌细胞增殖活性。Robatumumab 可用于骨肉瘤和尤文肉瘤的研究。 产品来源： https://www.medchemexpress.cn/robatumumab.html 研究领域：Protein Tyrosine Kinase/RTK 作用靶点：IGF-1R In Vitro: Robatumumab (0.02-80 nM; 0.5 or 4 h) downregulates IGF-IR and inhibits both basal and IGF-I-induced phosphorylation of IGF-IR and IRS-1 in SK-N-FI cells. In Vivo: Robatumumab (intravenous injection; 0.04 or 0.1 mg/mouse; twice weekly; 18 d) inhibits the SK-N-FI tumor growth in xenograft model. Robatumumab (intravenous injection; 0.02-0.5 mg/mouse; twice weekly; 35 d) inhibits the osteosarcoma growth in xenograft model. Robatumumab (intravenous injection; 0.1 or 0.5 mg/mouse; twice weekly; 14 d) inhibits the SJCRH30 and RD rhabdomyosarcoma cell growth in xenograft model. Robatumumab (intravenous injection; 0.1 or 0.5 mg/mouse; twice weekly; 2 w) blocks effectively pediatric tumor cell proliferation in vivo. Robatumumab (intravenous injection; 0.5 mg/mouse; once; day 11 post-inoculation) modulates the blood vessel formation via its antiangiogenesis effect. 相关产品：Ceritinib | Linsitinib | Picropodophyllin | BMS-754807 | BMS-536924 | GSK1838705A | Tranexamic acid | NVP-AEW541 | Ganitumab | AZD-3463 | GSK1904529A | NVP-ADW742 | PQ401 | XL228 | NVP-TAE 226 | Ginsenoside Rg5 | AG1024 | NBI-31772 | Chromeceptin | Teprotumumab | Indirubin Derivative E804 | Xentuzumab | ASP3026 | AZ7550 Mesylate | Figitumumab | Dalotuzumab | I-OMe-Tyrphostin AG 538 | IGF-1R inhibitor-2 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。