CTX-471 产品活性：CTX-471 是 CD137 的全人源单克隆抗体。CTX-471 对重组人、食蟹猴 CD137 和小鼠 CD137 具有结合亲和力，Kd 值分别为 50 nM、61 nM 和 748 nM。CTX-471 可用于免疫调节和癌症的研究。 产品来源： https://www.medchemexpress.cn/ctx-471.html 研究领域：Immunology/Inflammation 作用靶点：Interleukin Related In Vitro: CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 binds to a unique epitope on CD137. CTX-471 (0.1-100 nM; 1, 10 μg/mL; 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro. In Vivo: CTX-471 (i.p.; 150 μg) exhibits curative monotherapy activity in various syngeneic tumor models and shows a unique ability to cure mice of very large tumors. CTX-471 (i.v.; 10-80 mg/kg; on days 0, 7, 14, and 21) is well tolerated, with no signs of hepatic toxicity in high doses. 相关产品：Resatorvid | Disulfiram | Polyinosinic-polycytidylic acid | Raleukin | Deucravacitinib | Dupilumab | Tocilizumab | Apilimod | Oxidopamine hydrobromide | LMT-28 | Theophylline | Secukinumab | Clofazimine | Sodium metatungstate | Benzbromarone | SC144 | Hydrocortisone hemisuccinate | LY3509754 | ODN 2216 | Muscone | Diacerein | JTE-607 | Ixekizumab | APY0201 | Risankizumab | Lysophosphatidylcholines | Ustekinumab | Fibrinogen (Bovine) 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。