Sulanemadlin 产品活性：Sulanemadlin (ALRN-6924) 是一种可穿透细胞膜的，基于 p53 的强效拟肽大环。Sulanemadlin 是 p53-MDM2，p53-MDMX，或 p53 和 MDM2 和 MDMX 蛋白-蛋白相互作用的抑制剂。Sulanemadlin 可用于癌症研究。 产品来源： https://www.medchemexpress.cn/sulanemadlin.html 研究领域：Apoptosis 作用靶点：MDM-2/p53 In Vitro: Sulanemadlin (0-10 μM, 24 h) induces reversible, dose-dependent cell cycle arrest in CD34+ human bone marrow cells, and protects cells from Topotecan (HY-13768)-induced DNA damage. In Vivo: Sulanemadlin (5-20 mg/kg, i.v.) shows antitumor activity in multiple TP53-WT subcutaneous mouse xenograft models. Sulanemadlin (2.4 mg/kg, daily with for 5 days, 24 h prior to daily 1.5 mg/kg Topotecan) protects mice against Topotecan-induced neutropenia and gastrointestinal toxicity in mice, without diminishing Topotecan antitumor activity in TP53-mutant cancer models. PK properties of Sulanemadlin. Species Dose (mg/kg) Cmax (μg/mL) AUCall (μg·h/mL) T1/2 (h) CL (mL/h/kg) Mouse 5 67.8 450 2.2 11 Rat 5 95.9 223 2.0 24 Monkey 5 137 914 4.9 5.9 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Peptide Library | Nutlin-3a | Minocycline hydrochloride | Pifithrin-α hydrobromide | Idasanutlin | GSK3326595 | Navtemadlin | Eprenetapopt | CBL0137 hydrochloride | UC2288 | Amifostine | MD-224 | Siremadlin | RG7112 | Milademetan | Pifithrin-α, p-Nitro, Cyclic | NSC319726 | Pifithrin-μ | Alrizomadlin | Pifithrin-β hydrobromide | Higenamine hydrochloride | Kevetrin hydrochloride | COTI-2 | C16-Ceramide | RITA | NVP-CGM097 | p53 Activator 7 | Flubendazole | SP-141 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。