耗材描述
QEQLERALNSS TFA
产品活性:QEQLERALNSS TFA 是一种由促红细胞生成素衍生的螺旋 B 表面肽 (HBSP),具有组织保护活性。 QEQLERALNSS TFA 保护心肌细胞凋亡 (apoptosis)。
产品来源: https://www.medchemexpress.cn/qeqleralnss-tfa.html
研究领域:Apoptosis
作用靶点:Apoptosis
In Vitro: QEQLERALNSS (2.5 and 25 ng/mL; 12 h) clearly decreases TNF-α-induced apoptosis of cardiomyocytes.
QEQLERALNSS (2.5 ng/mL; 5 min) activates critical signaling pathways of cell survival, including Akt, ERK1/2, and STAT3 in cardiomyocytes.
In Vivo: QEQLERALNSS (8 nmol/kg; i.p.; daily for 2 weeks) shows protective effects on ischemia reperfusion and Cyclosporin A (HY-B0579) induced renal injury in rats.
QEQLERALNSS (30 μg/kg; s.c.; three times a week for 6 month) results in a significant decrease in the number of apoptotic cardiomyocytes in the cardiac sections compared with the control in DCM hamsters.
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