Neuropeptide AF (cattle) 产品活性：Neuropeptide AF (cattle) 是一种酰胺化的十八肽，是 RFamide 神经肽。Neuropeptide AF (cattle) 充当 Mas 相关基因受体 A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 约为 60 nM) 和 MrgprC11 (EC50 约为 300 nM) 的配体。Neuropeptide AF (cattle) 也激活 G 蛋白偶联受体 NPFF1 (Neuropeptide Y Receptor) (EC50 约为 25-325 nM) 和 NPFF2 (EC50 约为 1-5 nM)。Neuropeptide AF (cattle) 显示出抗阿片和相关的疼痛调节作用。 产品来源： https://www.medchemexpress.cn/neuropeptide-af-cattle.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Mas-related G-protein-coupled Receptor (MRGPR) | Neuropeptide Y Receptor In Vitro: Neuropeptide AF (NPAF) (50, 100, 150, 300, and 600 nM) induces a piecemeal degranulation in bone marrow-derived mucosal mast cells (BMMCs). Neuropeptide AF can be considered as a novel modulator of BMMC activity in the neuro-immune communication in the gastrointestinal tract. In Vivo: Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST). 相关产品：MrgprX2 antagonist-1 | BAM(8-22) | BIBO3304 TFA | Galanin (1-30), human | HT-2157 | MS47134 | SHA 68 | MrgprX2 antagonist-8 | Spexin | (R)-ZINC-3573 | MK-0557 | PAMP-12 (unmodified) | BIIE-0246 | Neuropeptide Y (human,rat,mouse) (TFA) | BIBP3226 TFA | MRGPRX1 agonist 1 | Galanin Receptor Ligand M35 | JNJ-31020028 | CGP71683 hydrochloride | [Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA | L 152804 | MRGPRX4 modulator-1 | MRGPRX4 modulator-2 | Pancreatic Polypeptide, human | RF9 | BMS-193885 | Neuropeptide Y (3-36) (human, rat) | Peptide YY (PYY) (3-36), porcine TFA | RFRP-3(human) 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。