耗材描述
Nocistatin
产品活性:Nocistatin 是一种神经肽,是孤儿类阿片受体的内源性配体。 Nocistatin 还是神经肽伤害感受肽或孤啡肽 FQ (Noc/OFQ) 的功能性拮抗剂。Nocistatin 通过 Gi/o 蛋白介导途径抑制 5-HT 释放。Nocistatin 阻断 Nociceptin 诱导的异常性疼痛和痛觉过敏。
产品来源: https://www.medchemexpress.cn/nocistatin.html
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Opioid Receptor
In Vitro: In the isolated organ bath studies Nocistatin (1 pM-1μM) inhibits the prostaglandin- and the KCl-evoked contractions in the uterus dose-dependently. Nocistatin, generated locally in the uterus, exerts an inhibitory effect, the mechanism being mediated in part by Ca2+-dependent K+ channels, the elevation of cAMP levels and sensory neuropeptides.
In Vivo: Intrathecal administration of Nocistatin (10 pg-1 μg) nociceptin or orphanin FQ (Noc/OFQ) induces pain responses including allodynia and hyperalgesia. Simultaneous administration of Nocistatin blocks the allodynia and hyperalgesia induced by Noc/OFQ.
Nocistatin also attenuates the allodynia and hyperalgesia evoked by prostaglandin E2 and the inflammatory hyperalgesia induced by formalin or carrageenan/kaolin, and reversed the Noc/OFQ-induced inhibition of morphine analgesia at picogram doses.
Nocistatin counteracted the impairment of learning and memory induced by Noc/OFQ or scopolamine. Nocistatin is widely present in the spinal cord and brain. Although Nocistatin does not bind to the Noc/OFQ receptor, it binds to the membrane of mouse brain and spinal cord with a high affinity.
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