耗材描述
[DPro5] Corticotropin Releasing Factor, human, rat
产品活性:[DPro5] Corticotropin Releasing Factor, human, rat 是促肾上腺皮质激素释放因子/激素 R2 的选择性激动剂。促肾上腺皮质激素释放因子 (CRF) 是一种下丘脑激素,能刺激肾上腺皮质激素 (ACTH) 和 β-内啡肽的分泌。[DPro5] Corticotropin Releasing Factor, human, rat 不引起典型的焦虑效应,但能够调节大鼠的学习和记忆过程。
产品来源: https://www.medchemexpress.cn/dpro5-corticotropin-releasing-factor-human-rat.html
研究领域:GPCR/G Protein
作用靶点:CRFR
In Vitro: [DPro5] Corticotropin Releasing Factor, human, rat (1 nM; 1 h) diminishes the amplitude of hippocampal population spike and prevents the onset of long-term potentiation (LTP).
In Vivo: [DPro5] Corticotropin Releasing Factor, human, rat (0.01-1 μg; i.c.v.; single dose) doesn’t induce the typical anxiogenic effect, but produces a nonspecific suppression of behavior in Sprague-Dowley rats. And [DPro5] Corticotropin Releasing Factor, human, rat also enhances the short-term memory to a maximum degree and prevented the memory loss induced by diazepam.
相关产品:Antalarmin hydrochloride | R121919 | Verucerfont | CRF, bovine TFA | Antisauvagine-30 TFA | Cortagine | NBI-27914 | Urocortin III, mouse TFA | Urocortin, human | CP 376395 | DMP 696 | Pexacerfont | Stressin I TFA | Tildacerfont | α-Helical CRF(9-41) | Urocortin, rat | [DPro5] Corticotropin Releasing Factor, human, rat TFA | Emicerfont | NVS-CRF38 | Sauvagine TFA | Urotensin I | (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) | (Tyr0)-Urocortin, rat | a-Helical Corticotropin Releasing Factor (12-41) | a-Helical Corticotropin Releasing Factor (9-41)
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