SARS-CoV-2-IN-34 产品活性：SARS-CoV-2-IN-34 (S-20-1) 是一种具有广谱抑制活性的，可穿透血脑屏障的 pan-coronavirus (CoV) fusion 抑制剂。SARS-CoV-2-IN-34 有效抑制伪型和真型 SARS-CoV-2 和其伪型变体 (VOCs) 的感染效应。SARS-CoV-2-IN-34 对 SARS-CoV-2 S1 和 S2 蛋白的 HR1 和 RBD 结构域具有高度亲和性。SARS-CoV-2-IN-34 可用于感染的研究。 产品来源： https://www.medchemexpress.cn/sars-cov-2-in-34.html 研究领域：Anti-infection 作用靶点：SARS-CoV In Vitro: SARS-CoV-2-IN-34 (0.1-100 μM; 30 min) inhibits infection by PsV of SARS variants on Huh-7 and Caco-2 cells with IC50s values ranging from 0.54 to 10.23 μM and inhibits infection of pseudotyped SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, and bat SARSr-CoV WIV1 with IC50s ranging from 1.30 to 12.02 μM. SARS-CoV-2-IN-34 (0.1-100 μM; 30 min) inhibits the replication of authentic SARS-CoV 2 on Caco-2 cell line with an IC50 value of 8.14 μM and inhibits authentic HCoV-OC43 and HCoV-229E infection in RD cells and Huh-7 cells with IC50s of 6.25 and 9.46 μM, respectively. SARS-CoV-2-IN-34 (0.1-100 μM; 2-4 h) potently inhibits cell-cell fusion mediated by S protein of SARS-CoV-2, SARS-CoV, MERS CoV, HCoV-229E and HCoV-NL63 with IC50s ranging from 1.47 to 5.44 μM. SARS-CoV-2-IN-34 (50 μM; 1 h) inhibits SARS-CoV-2 infection at the early stage of viral entry. SARS-CoV-2-IN-34 (0-2 μM) shows binding effects to S1, RBD and HR with Kd value of 67, 61 and 277 nM, respectively. In Vivo: SARS-CoV-2-IN-34 (60 and 80 mg/kg; intranasal route 0.5 h pre- or post-challenge with HCoV-OC43 and SARS-CoV-2 Delta) effectively protects mice from infection. SARS-CoV-2-IN-34 (50 mg/kg; i.p. and p.o. once ) shows good oral bioavailability and higher absorption rate under fed conditionsis, it is expected to have potential oral bioavailability. 相关产品：Chloroquine | Dexamethasone | Thapsigargin | ALC-0315 | Imatinib | Nirmatrelvir | Aloxistatin | Remdesivir | Imiquimod | Paquinimod | Hydroxychloroquine | Brequinar | GSK3326595 | Molnupiravir | Auranofin | Ritonavir | Methylprednisolone | Favipiravir | Ivermectin | Emodin | Punicalagin | Camostat mesylate | Asunaprevir | Cepharanthine | Zotatifin | Grazoprevir | EIDD-1931 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。