Bulevirtide 产品活性：Bulevirtide (Myrcludex B) 是 NTCP 抑制剂，是一种线性脂肽。Bulevirtide 可抑制 HBV 和 HDV 进入肝细胞，阻断 HBV 在肝细胞中的感染，并参与 HBV 转录抑制。Bulevirtide 可用于 HDV 感染和代偿性肝硬化的研究。 产品来源： https://www.medchemexpress.cn/bulevirtide.html 研究领域：Anti-infection 作用靶点：HBV In Vitro: Bulevirtide (200 nM, 24 h) inihibits NTCP through non-covalent binding in a time- and dose-dependent manner, transfer to a newly synthesized NTCP molecule. Bulevirtide (Huh7-NTCP cells, 2 μM, 9 days) exhibits potential antiviral activity as replication inhibitor, which blocks upregulation of NTCP mediated-HBV replication in Huh7-NTCP cells . In Vivo: Bulevirtide (2 μg/g, s.c. for everyday) prevents HBV spreading from infected human hepatocytes in uPA/SCID mice, hinders amplification of the cccDNA pool in initially infected hepatocytes. Bulevirtide (2 μg/g/d, s.c. for 3 weeks) blocks HBV cell entry in uPA/SCID mice through addressing the hepatocyte component rather than affecting virion productivity within the infected hepatocyte or the half-life of these cells. Bulevirtide (5 μg,s.c., twice a day for 4 days) blocks upregulation of NTCP mediated-HBV replication in C57BL/6 mice as a replication inhibitor. 相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | Bioactive Compound Library Plus | Peptide Library | Doxorubicin hydrochloride | Nicotinamide | Punicalagin | OSS_128167 | Lamivudine | RO8191 | Tenofovir | Estradiol benzoate | Vesatolimod | Isochlorogenic acid A | Entecavir monohydrate | Catalpol | RG7834 | Thiamine hydrochloride | Selgantolimod | 4,5-Dicaffeoylquinic acid | Osthole | Osalmid | Azvudine hydrochloride | Punicalin | Cetylpyridinium chloride | Adefovir | Adefovir dipivoxil | Pseudolaric Acid B | Merimepodib | Morphothiadin | Bicyclol | Tenofovir Disoproxil 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。