Lonodelestat TFA 产品活性：Lonodelestat TFA (POL6014 TFA) 是有效的、具有口服活性的、选择性的人中性粒细胞弹性蛋白酶(hNE) 的肽类抑制剂。Lonodelestat TFA 具有囊性纤维化 (CF) 研究的潜力 . 产品来源： https://www.medchemexpress.cn/lonodelestat-tfa.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Elastase In Vivo: Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice. Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001). 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Macrocyclic Compound Library | Peptide Library | Elastase, Porcine pancreas | Sivelestat | Alvelestat | DMP 777 | GW311616 | BAY-678 | BAY-85-8501 | Secologanoside | ZD-0892 | FK706 | Freselestat quarterhydrate | 19α-Hydroxyasiatic acid | AE-3763 | Chrysophanol 8-O-glucoside | Lodelaben | Lonodelestat | Skullcapflavone I | SSR69071 | ZD8321 | Ala-Ala-Pro-Val-chloromethylketone | Aristololactam IIIa | Cyclotheonellazole A | Elafin(human) | Elasnin | Elastase-IN-1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。