Allo-aca 产品活性：Allo-aca 是一种瘦素肽模拟物，是一种有效的、特异性的瘦素受体 (leptin receptor) 拮抗剂肽。Allo-aca 在多种体外和体内模型中阻断瘦素信号传导和作用。 产品来源： https://www.medchemexpress.cn/allo-aca.html 研究领域：Others 作用靶点：Others In Vitro: Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM. Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca inhibits VEGF mitogenic effects. Allo-aca inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells. In Vivo: In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively. 相关产品：Bioactive Compound Library Plus | Peptide Library | Digitonin | 5-Ph-IAA | FLAG peptide | 3X FLAG peptide | TCEP hydrochloride | Monocrotaline | Tocofersolan | Pronase E (Activity ≥ 7000 U/g) | DPPH | DNase I, Bovine pancreas | NMDI14 | O-Propargyl-Puromycin | Human IgG1 kappa, Isotype Control | Phytohemagglutinin | Hyaluronidase | Biotinyl tyramide | MYLS22 | Pertussis Toxin | N,N-Dimethylformamide | Kifunensine | OVA Peptide (323-339) | L-Tryptophan | 6-Aminonicotinamide | Lauryl maltose neopentyl glycol | Alkyne-phenol | Potassium oxonate | OVA Peptide(257-264) TFA | CHAPS | Teriparatide 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。