Alamandine 产品活性：Alamandine 是一种血管活性肽，是肾素-血管紧张素系统 (RAS) 的成员，还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可通过抗高血压作用来保护肾脏和心脏。 产品来源： https://www.medchemexpress.cn/alamandine.html 研究领域：GPCR/G Protein | Metabolic Enzyme/Protease 作用靶点：Angiotensin Receptor | Angiotensin-converting Enzyme (ACE) In Vitro: Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood.? Alamandine elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling.? Alamandine decreases secretion, expression, and blood levels of leptin. Alamandine induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes. In Vivo: Alamandine (0.15 ?μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide. 相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Metabolism/Protease Compound Library | Anti-Cardiovascular Disease Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | Angiogenesis-Related Compound Library | Peptide Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Heterocyclic Compound Library | Antihypertensive Compound Library | Protease Inhibitor Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Angiotensin II human | Losartan | Ursodeoxycholic acid | Captopril | Telmisartan | Tranilast | Valsartan | A 779 | Buloxibutid | Enalapril maleate | MLN-4760 | (Z)-Guggulsterone | AVE 0991 | Irbesartan | Candesartan | Nitrosoglutathione | Ramipril | Diminazene aceturate | YS-49 | Lisinopril dihydrate | Olmesartan | Sinapinic acid | BMS-265246 | Olodanrigan | PD 123319 ditrifluoroacetate 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。