PINT-87aa 产品活性：PINT-87aa 是一种 87 个氨基酸的肽，由长的基因间非蛋白质编码 RNA p53 诱导的转录本 (LINC-PINT) 的环状形式编码。PINT-87aa 可直接与聚合酶相关因子复合物 (PAF1c) 相互作用并抑制多种癌基因的转录延伸。PINT-87aa 在体外和体内抑制胶质母细胞瘤细胞增殖。 产品来源： https://www.medchemexpress.cn/pint-87aa.html 研究领域：Cell Cycle/DNA Damage 作用靶点：DNA/RNA Synthesis In Vitro: Both 456 and 4121 cells overexpressing PINT-87aa exhibits G1 arrest and reduces cell proliferation without obvious cellular toxicity, whereas PINT-87aa K.O. SW1783 and Hs683 cells shows increased cell cycle and cell proliferation rates. The mRNA of PAF1 downstream genes (CPEB1, SOX-2, c-Myc, etc.) is inhibited transcriptionally in PIN87aa-overexpressing 456 and 4121 cells compared with that in control cells. In Vivo: 456 and 4121 cells stably overexpressing PINT-87aa exhibits decreased in situ tumorigenic potential compared with control cells, as assessed by tumor growth and animal survival in mice. PINT-87aa K.O. cells results in significantly increased xenograft tumor volumes of nude mice. 相关产品：Cycloheximide | Actinomycin D | Oxaliplatin | Gemcitabine | Bleomycin sulfate | Carboplatin | Mitomycin C | Cytarabine | 5-BrdU | Methotrexate | Streptozotocin | Anisomycin | Fludarabine | ART558 | Propidium Iodide | Thymidine | Hydroxyurea | Daunorubicin hydrochloride | Remdesivir | Capecitabine | Brequinar | Urolithin A | Folic acid | CX-5461 | α-Amanitin | Branaplam | Epirubicin hydrochloride | Plicamycin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。