耗材描述
RAGE antagonist peptide TFA
产品活性:RAGE antagonist peptide TFA 是一种晚期糖基化终产物 (RAGE) 拮抗剂。RAGE antagonist peptide TFA 可阻断 RAGE 和几个重要配体 HMGB-1,S100P,S100A4 的结合。RAGE antagonist peptide TFA 具有抗肿瘤和抗炎活性。
产品来源: https://www.medchemexpress.cn/rage-antagonist-peptide-tfa.html
研究领域:Neuronal Signaling
作用靶点:Amyloid-β
In Vitro: RAGE antagonist peptide TFA (RAP) reduces the ability of the ligands to stimulate RAGE activation of NFκB in cancer cells in vitro.
In Vivo: RAGE antagonist peptide TFA (RAP, 100 μg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo.?
RAGE antagonist peptide TFA (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth.?
In mice bearing asthma, RAGE antagonist peptide TFA (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide TFA also reduces total, cytoplasmic and nuclear levels of β-catenin, enhances β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function.
相关产品:Bioactive Compound Library Plus | Peptide Library | DAPT | β-Amyloid (25-35) | Thioflavin T | β-Amyloid (1-42), human TFA | FPS-ZM1 | Rutin | Colivelin TFA | Azeliragon | Santacruzamate A | 20(S)-Ginsenoside Rg3 | Ginsenoside Rg1 | β-Amyloid (1-42), (rat/mouse) | Tolcapone | Methoxy-X04 | Aducanumab | Geniposide | Notoginsenoside R1 | Semagacestat | Ginsenoside Re | Bavachinin | Emrusolmin | Leucomethylene blue mesylate | Glimepiride | Hoechst 34580 tetrahydrochloride | Hematoxylin | Valiltramiprosate | Direct Blue 1 | β-Amyloid (1-40) (TFA) | β-Amyloid (42-1), human
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