RAGE antagonist peptide 产品活性：RAGE antagonist peptide 是一种晚期糖基化终产物 (RAGE) 拮抗剂。RAGE antagonist peptide (RAP) 可阻断 RAGE 和几个重要配体 HMGB-1、S100P、S100A4 的结合。RAGE antagonist peptide (RAP) 具有抗肿瘤和抗炎活性。 产品来源： https://www.medchemexpress.cn/rage-antagonist-peptide.html 研究领域：Neuronal Signaling 作用靶点：Amyloid-β In Vitro: RAGE antagonist peptide (RAP) reduces the ability of the ligands to stimulate RAGE activation of NFκB in cancer cells in vitro. In Vivo: RAGE antagonist peptide (RAP, 100 µg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo. RAGE antagonist peptide (RAP) reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth. In mice bearing asthma, RAGE antagonist peptide (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide also reduces total, cytoplasmic and nuclear levels of β-catenin, enhanced β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function. 相关产品：DAPT | β-Amyloid (25-35) | Thioflavin T | β-Amyloid (1-42), human TFA | FPS-ZM1 | Rutin | Colivelin TFA | Azeliragon | Santacruzamate A | 20(S)-Ginsenoside Rg3 | Ginsenoside Rg1 | β-Amyloid (1-42), (rat/mouse) | Tolcapone | Methoxy-X04 | Aducanumab | Geniposide | Notoginsenoside R1 | Semagacestat | Ginsenoside Re | Bavachinin | Emrusolmin | Leucomethylene blue mesylate | Glimepiride | Hoechst 34580 tetrahydrochloride | Hematoxylin | Valiltramiprosate | Direct Blue 1 | β-Amyloid (1-40) (TFA) | β-Amyloid (42-1), human 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。