Elabela(19-32) TFA 产品活性：Elabela(19-32) TFA 是与 apelin 受体 (APJ) 结合的 ELABELA (ELA) 活性片段。Elabela(19-32) TFA 激活 Gαi1 和 β-arrestin-2 信号通路，EC50 分别为 8.6 nM 和 166 nM。Elabela(19-32) TFA 诱导受体内在化，降低动脉压，对心脏产生正性肌力作用。 产品来源： https://www.medchemexpress.cn/elabela-19-32-tfa.html 研究领域：GPCR/G Protein 作用靶点：Apelin Receptor (APJ) | Arrestin In Vitro: Elabela(19-32) TFA (analogue 3) has a Ki of 0.93 nM for binding of radioligand apelin-13[Glp65, Nle75, Tyr77][125I]. Elabela(19-32) TFA has an EC50 of 36 nM in HEK293 cells transiently expressing the HA-hAPJ receptor. Elabela(19-32) TFA is slightly less potent than apelin-13 and ELA to elicit receptor internalization. Elabela(19-32) TFA (0.001 to 0.3 nM) has an EC50 of 1.5 pM in inducing changes in left ventricular developed pressure (LVDP) on the Langendorff perfused isolated rat heart. In Vivo: Elabela(19-32) TFA (analogue 3) is rapidly metabolized in rat plasma (t1/2 相关产品：Bioactive Compound Library Plus | Peptide Library | Barbadin | Apelin-13 TFA | [Pyr1]-Apelin-13 | ML221 | Abaloparatide TFA | Azelaprag | ML339 | BMS-986224 | ELA-32(human) TFA | Balixafortide TFA | Elabela(19-32) | CMF019 | TRV-120027 | UNC9994 hydrochloride | 7-Fluorotryptamine hydrochloride | MM 07 | (Rac)-Tavapadon | Apelin-12 | MM 54 | ALX 40-4C Trifluoroacetate | Apelin-17(human, bovine) | (Ala13)-Apelin-13 TFA | CCX-777 | ELA-21 (human) | GPR35 agonist 2 | ML192 | Apelin-36(human) 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。