AUNP-12 产品活性：AUNP-12 (NP-12) 是 PD-1 信号通路的一种多肽拮抗剂，在抑制淋巴细胞增殖和效应功能方面对 PD-L1 和 PD-L2 具有等效的拮抗作用。AUNP-12 具有免疫激活作用、良好的抗肿瘤活性，具有更好的研究免疫相关不良事件 (irAEs) 的潜力。 产品来源： https://www.medchemexpress.cn/np-12.html 研究领域：Immunology/Inflammation 作用靶点：PD-1/PD-L1 In Vitro: AUNP-12 displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions . AUNP-12 rescues the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively. AUNP-12 is also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition of in vitro human PBMC proliferation, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively. 相关产品：Bioactive Compound Library Plus | Peptide Library | Atezolizumab | Pembrolizumab | Cilengitide | Nivolumab | BMS-1 | BMS-202 | Anti-Mouse PD-1 Antibody (RMP1-14) | JQ-1 (carboxylic acid) | Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) | Durvalumab | Tomivosertib | Avelumab | Pembrolizumab (anti-PD-1) | Sulindac | CA-170 | Camrelizumab | Tislelizumab | BMS-1166 | INCB086550 | BMS-8 | Peresolimab | Fraxinellone | PD-1/PD-L1-IN-9 | Sintilimab | Toripalimab | Rosnilimab | WL12 | Evixapodlin | PROTAC PD-1/PD-L1 degrader-1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。