耗材描述
CREBtide TFA
产品活性:CREBtide TFA 是一种类似 CREB (cAMP反应元件结合蛋白) 的肽。CREBtide TFA 是一种合成的含 13 个氨基酸的肽。CREBtide TFA 可作为 PKA 底物。
产品来源: https://www.medchemexpress.cn/crebtide-tfa.html
研究领域:Stem Cell/Wnt | TGF-beta/Smad
作用靶点:PKA
In Vitro: delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent Km of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (Km=39 μM), the synthetic peptide substrate most often employed for cAK measurement. The Vmax values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent Km of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the Vmax value is 3.2 mumol/(min.mg). Both delta-CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibits by delta-CREB is retained by the peptide.
相关产品:Bioactive Compound Library Plus | Peptide Library | Staurosporine | Bucladesine sodium | H-89 dihydrochloride | 8-Bromo-cAMP sodium salt | Fasudil Hydrochloride | D-Mannitol | K-252a | Daphnetin | Rp-cAMPS sodium salt | KT5720 | AT13148 | PKA Inhibitor Fragment (6-22) amide TFA | AT7867 | CCG215022 | Gliotoxin | PKA-IN-1 | PKI(5-24) | HA-100 | PKI 14-22 amide,myristoylated | 8-CPT-Cyclic AMP sodium | Metadoxine | KT5823 | Bilobetin | PKI 14-22 amide,myristoylated TFA | CREBtide | H-8 dihydrochloride | Jaspamycin
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