耗材描述
Melanin Concentrating Hormone, salmon
产品活性:Melanin Concentrating Hormone, salmon是最初在硬骨鱼的垂体中发现的19个氨基酸组成的神经肽,它调节食物摄入,能量平衡,睡眠状态和心血管系统。 Melanin-concentrating hormone是 SLC-1/GPR24 和 MCHR2 的配体。
产品来源: https://www.medchemexpress.cn/Melanin_Concentrating_Hormone,_salmon.html
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:MCHR1 (GPR24)
In Vitro: An orphan G protein-coupled receptor (SLC-1/GPR24) has been identified as a receptor for MCH (MCHR1). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein.
In Vivo: Melanin Concentrating Hormone stimulates appetite. Continuous infusion of Melanin Concentrating Hormone into the ventricular system increases food intake for 7-8 days. Intracerebroventricular infusion of Melanin Concentrating Hormone (10 μg/day) causes a slight but significant increase in body weight in mice maintained on the regular diet. Chronic stimulation of the brain Melanin Concentrating Hormone system could cause obesity in mice.
相关产品:Bioactive Compound Library Plus | Peptide Library | SNAP 94847 hydrochloride | MCH(human, mouse, rat) TFA | Melanin Concentrating Hormone, salmon TFA | AZD1979 | ALB-127158(a) | [Ala17]-MCH | ATC0175 | Ethyl linolenate | GW-803430 | MCH-1 antagonist 1 | MCHR1 antagonist 2 | TC-MCH 7c | (Phe13,Tyr19)-MCH (human, mouse, rat) | Ac-hMCH(6-16)-NH2 | AMG-076 | BMS-814580 | hMCH-1R antagonist 1 | MCHR1 antagonist 3 | Neuropeptide EI, rat | BMS-819881 | MCHR1 antagonist 1 | NGD-4715 | SB-568849
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