耗材描述
Bradykinin (2-9)
产品活性:Bradykinin (2-9) 是一种氨基截短的激肽肽。Bradykinin (2-9) 是由氨基肽酶 P 切割形成的一种 Bradykinin 代谢物。
产品来源: https://www.medchemexpress.cn/Bradykinin_2-9.html
研究领域:GPCR/G Protein
作用靶点:Bradykinin Receptor
In Vitro: The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8).
相关产品:Bioactive Compound Library Plus | Peptide Library | Bradykinin | Icatibant | [Des-Arg9]-Bradykinin acetate | SSR240612 | Lobradimil | Lys-[Des-Arg9]Bradykinin TFA | Bradykinin (1-7) | ELN-441958 | Fulimetibant | MEN 11270 | [Tyr8] Bradykinin | Bradykinin (1-5) | Bradykinin (1-6) | R715 | Sar-[D-Phe8]-des-Arg9-Bradykinin | B 9430 | Bombinakinin M | Des-Arg9-[Leu8]-Bradykinin acetate | Fasitibant chloride | FR173657 | Lys-(Des-Arg9,Leu8)-Bradykinin | Lys-Bradykinin | Lys-[Des-Arg9]Bradykinin | Lys-[Hyp3]-Bradykinin | Methionyl-Lysyl-Bradykinin
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