AF12198 产品活性：AF12198 是针对人类I型白介素-1 受体 (IL1R1) (IC50=8 nM) 的有效，选择性和特异性肽拮抗剂，但不是针对人类 II 型受体 (IC50=6.7 µM) 或鼠 I 型受体 (IC50>200 µM)。AF12198 抑制 IL-1 诱导的 IL-8 产生 (IC50=25 nM) 和 IL-1诱导的细胞间粘附分子 1 (ICAM-1) 表达 (IC50=9 nM)。AF12198 具有抗炎活性，并在体内阻断了对 IL-1 的反应。 产品来源： https://www.medchemexpress.cn/af12198.html 研究领域：Immunology/Inflammation 作用靶点：Interleukin Related In Vitro: AF12198 competes for binding of?125I-IL-1α with an IC50?of 8.0 nM, nearly equal to that of IL-1ra, IC50 of 4.0 nM for the type I receptor.AF12198 (0-5 ng; 8 hours)? inhibits IL-6 induction with an IC50 of 15 μM whereas IL-1ra inhibits with an IC50?of 2 nM?in heparinized human?primate blood. Meanwhile, With blood from cynomolgus monkeys, the IC50?values are 17 μM for AF12198 and 30 nM for IL-1ra. Additionally, AF12198 or IL-1RA alone does not induce IL-6 in blood from either humans or cynomolgus monkeys. In Vivo: AF12198 (intravenous infusion; 16?mg/kg; 30?min before LPS intravenous injection) significantly attenuates the increase in lung MPO activity induced by LPS in acute lung inflammation and it reduces the lung microvascular leakage from rats inflamed with LPS at the 4?h (32.6%), 12?h (50.1%) and 24?h (65.3%) after LPS. 相关产品：Bioactive Compound Library Plus | Peptide Library | Resatorvid | Disulfiram | Polyinosinic-polycytidylic acid | Raleukin | Deucravacitinib | Dupilumab | Tocilizumab | Apilimod | Oxidopamine hydrobromide | LMT-28 | Theophylline | Secukinumab | Clofazimine | Sodium metatungstate | Benzbromarone | SC144 | Hydrocortisone hemisuccinate | LY3509754 | ODN 2216 | Muscone | Diacerein | JTE-607 | Ixekizumab | APY0201 | Risankizumab | Lysophosphatidylcholines | Ustekinumab | Fibrinogen (Bovine) 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。