DAPTA 产品活性：DAPTA 是一种合成肽，为 CCR5 抑制剂，同时具有抗 HIV 的活性。 产品来源： https://www.medchemexpress.cn/DAPTA.html 研究领域：GPCR/G Protein | Immunology/Inflammation | Anti-infection 作用靶点：CCR | HIV In Vitro: DAPTA (1 nM) inhibits HIV-1 replication in monocytes/macrophages (M/M) by >90%. DAPTA blocks HIV entry and prevents HIV-1 infection. DAPTA reduces CCR5 mAb binding in human primary macrophages. DAPTA potently blocks R5 gp120-mediated neuronal apoptosis. DAPTA is even more potent in preventing neuronal apoptosis than the CCR5 antagonist TAK-779. DAPTA potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5. DAPTA (1 nM) blocks formation of the gp120/sCD4 complex with CCR5. DAPTA inhibits the binding of gp120BaL/sCD4 to CCR5 (Cf2Th/synR5) cells with IC50 of 55 ± 0.08 pM. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Antiviral Compound Library | Small Molecule Immuno-Oncology Compound Library | Drug Repurposing Compound Library | Endocrinology Compound Library | Peptide Library | Anti-Pulmonary Fibrosis Compound Library | Chemokine Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Cytokine Inhibitors Library | Multi-Target Compound Library | Bioactive Compound Library Max | Chloroquine | Doxorubicin hydrochloride | 5-Fluorouracil | Q-VD-OPh | Valproic acid | Pirfenidone | Panobinostat | Shikonin | Probenecid | Kaempferol | Dimethyl fumarate | Hydroxyurea | Plerixafor | Maraviroc | Birinapant | Baicalin | Flavopiridol | Ritonavir | Ivermectin | Fasudil Hydrochloride | Ebselen | Rolipram | RS 504393 | Lysozyme from chicken egg white | CK-666 | Betulinic acid | Oleanolic Acid 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。