耗材描述
NN1177
产品活性:NN1177 是一种长效 GLP-1/胰高血糖素受体 共激动剂。NN1177 可诱导饮食诱导肥胖 (DIO) 小鼠出现剂量依赖性体重减轻。
产品来源: https://www.medchemexpress.cn/nn1177.html
研究领域:GPCR/G Protein | Metabolic Enzyme/Protease
作用靶点:GCGR | GLP Receptor | Cytochrome P450
In Vitro: NN1177 (100 nM, 3 days) reduces CYP3A4 mRNA expression (57.2-71.7%) and activity (18.5-51.5%) in freshly isolated human hepatocytes.
In Vivo: NN1177 (3 or 5 nmol/kg, s.c.) induces body weight loss, loss of fat mass, and improvement in glucose tolerance in diet-induced obese (DIO) mice.
NN1177 (0.75-4 nmol/kg, s.c., once daily, 8 weeks) reduces liver fat and inflammatory and fibrosis relevant biomarkers in C57Bl/6 mice fed a fructose and high fat rich diet (NASH model).
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