Protease-Activated Receptor-2, amide 产品活性：Protease-Activated Receptor-2, amide (SLIGKV-NH2) 是一种高效的蛋白酶活化受体-2 (PAR2) 活化肽。 产品来源： https://www.medchemexpress.cn/Protease-Activated_Receptor-2,_amide.html 研究领域：GPCR/G Protein 作用靶点：Protease Activated Receptor (PAR) In Vitro: The PAR2-activating peptides used are: SLIGKV-OH, SLIGRL-OH, SLIGKV-NH2, SLIGRL-NH2. The synthetic agonist peptides mimicking the tethered ligand of PAR2, Ser-Leu-Ile-Gly-Lys-Val (SLIGKV-OH), Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL-OH) and their amidated forms Ser-Leu-Ile-Gly-Lys-Val-amide (SLIGKV-NH2) Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH2) have also been demonstrated being able to activate the receptor without enzymatic cleavage, therefore, have been utilised as biological tools to examine physiological functions of PAR2. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation factors VIIa and Xa, cleave a specific extracellular amino-terminal domain of the receptor to reveal a 'tethered ligand', SLIGKV- and SLIGRL- for human and mouse/rat PAR2, respectively, which subsequently interacts with the activation domain of the receptor, initiating intracellular signaling pathways. The protease-activated receptor-2 (PAR2) has been implicated in the pathogenesis of several inflammatory and autoimmune disorders, and is expressed in a wide variety of human tissues and cells. PAR2 belongs to a family of seven transmembrane domain receptor proteins that are activated by proteolysis. Enzymatic digestion exposes an N-terminus ligand sequence that binds intramolecularly to the activation site on the extracellular loop II, initiating a G-protein-mediated cell-signalling cascade and nuclear factor-kappa B (NF-κB)-regulated gene transcription. 相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Anti-Cancer Compound Library | Peptide Library | Coagulation and Anti-coagulation Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Bioactive Compound Library Max | Vorapaxar | TRAP-6 | Trypsin | AZ3451 | SLIGRL-NH2 | PAR-4 Agonist Peptide, amide TFA | 2-Furoyl-LIGRLO-amide | SCH79797 | GB-88 | BMS-986120 | GB-110 hydrochloride | AZ8838 | I-191 | AC-55541 | FSLLRY-NH2 TFA | Parmodulin 2 | ENMD-1068 hydrochloride | PZ-128 | TFLLR-NH2(TFA) | Atopaxar | PAR-4 Agonist Peptide, amide | PAR-2-IN-1 | Protease-Activated Receptor-4 | PAR-2 (1-6) (human) | tcY-NH2 TFA | VKGILS-NH2 | Protease-Activated Receptor-1, PAR-1 Agonist TFA 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。