Histatin 5 产品活性：Histatin 5 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 活性，IC50 分别为 0.57 和 0.25 μM。 产品来源： https://www.medchemexpress.cn/Histatin_5.html 研究领域：Metabolic Enzyme/Protease 作用靶点：MMP In Vitro: Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC50, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the Km with a Ki of 15 μM. Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 μM inhibits state 2 respiration. 相关产品：Doxycycline hyclate | T-5224 | Ilomastat | Chloramphenicol | Astragaloside IV | Edaravone | Isoginkgetin | Cordycepin | GI254023X | Marimastat | Stigmasterol | Salvianolic acid A | o-Phenanthroline | Meloxicam | Actinonin | Batimastat | SB-3CT | Arctigenin | GW280264X | MMP-9-IN-1 | Chondroitin sulfate | Aderbasib | (-)-Epigallocatechin | TAPI-1 | Collagenase IV, Clostridium histolytica | Tranexamic acid | TAPI-2 | Collagenase, Type II 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。